Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice

Figure 4

Lobeglitazone regulates hepatic lipid metabolism in HFD-fed mice. (a) Protein expression of lipid metabolism-related genes in liver tissues. ß-actin was included as a loading control. (b) Expression levels of de novo lipogenesis-related genes in liver tissues. (c) Expression levels of cholesterol biosynthesis-related genes in liver tissues. (d) Expression levels of lipid droplet development-related genes in liver tissues. (e) Expression levels of fatty acid β-oxidation related genes in liver tissues. (f) Protein expression of pPPARγ (S273) and PPARγ in liver tissues. ß-ACTIN was included as a loading control. NU: normal chow diet- (NCD-) fed mice without treatment (NU, black bar), HU: HFD-fed mice without treatment (white bar), and HL: HFD-fed mice with lobeglitazone treatment (gray bar). Data are expressed as means ± SEM. p < 0.05, p < 0.001, and p < 0.0001, NU versus. HU group. ^#p < 0.05, ^##p < 0.001, and ^###p < 0.0001, HU versus. HL group.

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