6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARδ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells

Figure 4

Immunocytochemistry for ENaC in HEK293 cells treated with NaCl, 6-gingerol, and GSK0660. In HEK293 cells, the abnormal ENaC protein expression induced by NaCl treatment was normalized by 6-gingerol treatment. The effect of 6-gingerol was reversed by pretreatment with a PPARδ antagonist. Magnification is 200 times. All experiments were repeated three or more times. The statistical significance between the two experimental groups was marked as p < 0.001. Meaning of indications: Ctrl indicates an untreated normal control group, Na indicates an NaCl treated group, NaG indicates an NaCl and 6-gingerol treated group, and NaGG indicates an NaCl, 6-gingerol, and GSK0660 treated group.