A Reduction in ADAM17 Expression Is Involved in the Protective Effect of the PPAR-α Activator Fenofibrate on Pressure Overload-Induced Cardiac Hypertrophy

Figure 3

Fenofibrate attenuated angiotensin II-induced cardiac hypertrophy in cultured primary cardiomyocytes. After pretreated with fenofibrate (10 μM) for 1 hour, cardiomyocytes were then stimulated with 100 nM angiotensin II for 24 hours. (a) Cell surface area; (b) ANP mRNA level; (c) BNP mRNA level. Ang II represents angiotensin II; Feno represents fenofibrate; ^#p<0.05 versus control group; p<0.05 versus Ang II group. n=3 independent experiments.

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