Review Article

Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology

Figure 4

The regulatory function of microRNAs/peroxisome proliferator-activated receptors (PPARs) axis in obesity-associated cardiovascular risks. PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase; Akt: serine/threonine kinase 1; Nfat5: nuclear factor of activated T-cells 5; Rasa1: RAS p21 protein activator 1; Pknox1: Pbx/knotted 1 homeobox 1; M1/M2 macrophage: proinflammatory M1 macrophage /anti-inflammatory M2 macrophage.