Research Article

Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression

Figure 2

Hepatocyte fat accumulation after 12 weeks of pioglitazone treatment according to CAR activity. Representative hematoxylin and eosin staining of liver of mice. (a) CAR+/+ control. (b) CAR-/- control. (c) CAR+/+ TCPOBOP. (d) CAR+/+ with pioglitazone. (e) CAR-/- with pioglitazone. (f) CAR+/+ TCPOBOP with pioglitazone.