Rosiglitazone, a Ligand to PPAR, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation

Figure 2

Effect of rosiglitazone (RGZ) on vascular reactivity exerted by acethylcholine. The aortic reactivity was evaluated in sham-vehicle treated (a), aortic coarctated (AoCo)-vehicle treated (b), AoCo-RGZ treated (c), and AoCo-RGZ + bisphenol A diglycidyl ether (BADGE) treated (d) rats under basal conditions (●) or in presence of N(ω)-nitro-L-arginine-methyl-ester (L-NAME, 300μM) (■). The values represent the mean ± SEM (n=6 animals per group). One-way analysis of variance (ANOVA) post Tukey. ^∗P < 0.05 basal vs. L-NAME conditions.

(a) Sham-V

(b) AoCo-V

(c) AoCo-RGZ

(d) AoCo-RGZ + BADGE