Rosiglitazone, a Ligand to PPAR, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation

Figure 6

Effect of rosiglitazone (RGZ) on 8-hydroxy-2′-deoxyguanosine (8-OH-2-dG), a marker of oxidative stress-induced DNA damage in homogenate from aorta (a) and serum (b), and serum malondialdehyde (c) from sham or aortic coarctated (AoCo) rats treated with vehicle (V), rosiglitazone (5mg/kg, RGZ), or RGZ + bisphenol A diglycidyl ether (120 mg/kg, RGZ+BADGE). The values represent the mean ± SEM (n=6 animals of group). One-way analysis of variance (ANOVA) post Tukey. ^∗P < 0.05 Sham-V vs. AoCo-V, ^#P < 0.05 AoCo-V vs. AoCo-RGZ, and ^&P < 0.05 AoCo-RGZ vs. AoCo-RGZ+BADGE.

(a)

(b)

(c)