Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice

Figure 6

Effects of piperine treatment on oxidative stress, inflammation and apoptosis in cells. (a) Cell viability (). (b) and (c) MDA level and SOD activity (). (d) and (e) The levels of inflammatory factors in mice (n=6). (f) and (g) Caspase3 mRNA level and cleaved-caspase3 blot (). (h) The luciferase assay (). (i) The level of PPAR-γ (). (j) PPAR-γ protein expression (). (k) and (l) Cell viability and LDH release (). Data are expressed as mean ± SD. For (a)–(g) vs. PBS/vehicle group; vs. DOX/vehicle group. For (h) and (i), . Data were analyzed sing one-way ANOVA, followed by Tukey post hoc analysis.

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