Effects of Dual Peroxisome Proliferator-Activated Receptors and Activation in Two Rat Models of Neuropathic Pain

Figure 2

Antinociceptive effects of tesaglitazar on diabetic neuropathy pain. (a) Effects of i.p. injection of tesaglitazar (2, 10, or 20μg/kg) or vehicle on STZ-induced changes in PWT. Data are expressed as mean ± SEM of PWT in grams. (b) Effects of intraperitoneal injection of tesaglitazar (2, 10, or 20μg/kg) or vehicle on STZ-induced changes in blood glucose levels. Data are expressed as mean ± SEM of blood glucose in mg/dL. Rats received i.p. injection of (2, 10, or 20μg/kg) or vehicle at week 4 after STZ injection. Data are analyzed using one-way ANOVA test followed by Dunnett’s post hoc; all doses were compared to STZ/vehicle (P<0.05, n=5 rats per group).

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