Adenosine Receptor A1-A2a Heteromers Regulate EAAT2 Expression and Glutamate Uptake via YY1-Induced Repression of PPARγ Transcription

Figure 6

Schematic illustration of adenosine receptor A1-A2a heteromers regulates PPARγ transcription and EAAT2 expression in astrocytes. OGD promoted A1AR-A2aAR heteromer formation and upregulated YY1 expression to suppress the PPARγ transcription through recruitment of HDAC1 to the PPARγ promoter region, resulting in abolished EAAT2-mediated glutamate uptake.