|
| PPAR beta/delta target genes | Cellular biological function | References (for target genes) |
|
| Calcineurin A | Induction of cardiac vascularization, cardiac growth, and skeletal muscle remodeling [47, 48] | [15] |
| COX2 | An inflammatory angiogenic mediator and a key regulator of tumor angiogenesis [93, 122, 123] | [104] |
| VEGF | A key regulator of vasculogenesis and angiogenesis [74, 75, 76] | [105, 106] |
| MMP9 | A proinvasive matrix-degrading enzyme and a key regulator of tumor angiogenesis and metastasis [77, 78] | [69] |
| LEPTIN | Regulation of endothelial cell behavior and angiogenesis [79, 80, 81] | [107] |
| IL8 | A key angiogenic chemokine, a proinflammatory mediator, and a key regulator of tumor angiogenesis and progression [98, 111, 112, 114] | [18] |
| WT1 | An important regulator of tumor angiogenesis and progression [129] | [148] |
| NANOG | Regulation of self-renewal of cancer stem cells or cancer stem-like cells [149–151] | [149] |
| c-KIT | A potential marker of cancer stem-like cells [152]; promotion of tumor angiogenesis [155–158] and pathological ocular neovascularization [161] | [16] |
| PDGFB | A key regulator of angiogenesis and vasculogenesis [162–165] and vascular permeability and maturation [166–168] | [16] |
| PDGFR beta | A key regulator of angiogenesis and vasculogenesis [162–165], vascular permeability and maturation [166–168], and tumor progression [174, 175] | [16] |
| ANGPTL4 | Promotion of angiogenesis, tumor progression, and metastasis [178–182] | [183, 184] |
| PDK4 | Regulation of EMT and cell metabolism, and cancer progression [185–188] | [189] |
| FABP4 | Regulation of glucose and lipid metabolism; cell proliferation and apoptosis [190, 191] | [192] |
| CDKN1C | A prognostic factor for many types of cancer; regulation of angiogenesis and cancer hallmarks [193] | [17, 46] |
| SRC | Promotion of angiogenesis, cancer invasion, and tumor progression [194] | [194] |
| EDG2 | Enhancement of endothelial cell differentiation and vasculogenesis [195] | [195] |
| FOXO1 | Involvement of physiological, pathological, and developmental angiogenesis [196–198] | [199] |
| GLUT1 | Promotion of cancer cell metabolism and tumor growth [200, 201] | [202] |
| SLC1-A5 | Promotion of cancer cell metabolism and tumor progression [203, 204] | [202] |
|
