Diet Modifies Pioglitazone’s Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression

Figure 4

Effects of Pio on the hepatic transcriptome. (a, b) Principle component (PCA) and (c, d) heat map analyses of differentially expressed genes from RNA-Seq analyses of livers from (a, c) WT or (b, d) KO mice treated with control diet, Pio, HFD, or HFD and Pio. Heat map analyses are based on Pio-induced differences in gene expression. (e–h) Venn diagrams (generated using InteractiVenn [42]) depict overlap between differentially expressed genes by treatment group in WT (e, g) or KO (f, h) mice.

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