Diet Modifies Pioglitazone’s Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression

Figure 6

BETA Analyses of Pio’s Effects on Mitochondrial Gene Expression - (a) Venn diagram analysis depicting genes identified by BETA as most likely to be regulated by Pio-induced effects on liver RXR-DNA binding in WT mice on control versus HFD. (Input RXR-liver DNA binding data from the KO mice was insufficient to execute BETA.) (b) Nuclear genes encoding mitochondrial proteins identified by BETA as likely to be Pio-induced by PPARγ-dependent effects on liver RXR-DNA binding (genes in orange were identified from analyses of mice on control diet; those in blue from analyses of mice on HFD; and those in black from analyses of mice on either diet). The mitochondria illustration is adapted from an image freely available in the public domain at https://commons.wikimedia.org/wiki/File:Mitochondrial_electron_transport_chain%E2%80%94Etc4.svg.

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