The Model of PPARγ-Downregulated Signaling in Psoriasis
Table 1
Cell processes directly related to psoriasis and enriched with genes and proteins from the PPARγ-downregulated signaling. See complete results with additional statistics in supplemental materials, “PPRAG network analysis” file.
Name of the process or signaling
Source
Rank or Jaccard similarity (the closer to 10%, the more similarity)
Category
Keratinocyte activation in psoriatic arthritis
PS Collection
9.13%
Disease
Lesion size
PS subnetwork
46
Targets neighbors
Keratinocyte proliferation
PS subnetwork
100
Targets neighbors
Skin fibrosis
PS Collection
9.09%
Disease
T cell differentiation block in psoriasis
PS Collection
8.88%
Disease
Th17 cell and Th1 immune response in psoriatic arthritis
PS Collection
8.82%
Disease
Dendritic cell dysfunction in psoriatic arthritis
PS Collection
8.44%
Disease
T cell cytotoxic response against melanocytes in vitiligo
PS Collection
6.20%
Disease
Synovial fibroblast activation in psoriatic arthritis
PS Collection
8.18%
Disease
Inflammatory reaction in acne vulgaris
PS Collection
5.70%
Disease
Apoptotic keratinocyte clearance recession in systemic lupus erythematosus
