The Model of PPARγ-Downregulated Signaling in Psoriasis
Table 2
List of PS pathways associated with members of PPARγ-downregulated signaling associated with psoriasis. See complete results with additional statistics in supplemental materials, “PPRAG network analysis” file.
Pathway name
# of entities
Overlap
Percent overlap
value
Jaccard similarity
Pathway taxonomy top category
EGFR—expression targets in skin
98
26
26
4.68-11
10.28%
Biomarkers
GPCRs family—expression targets in lymphoid system and blood
89
24
26
1.97-10
9.76%
Biomarkers
Adipokine production by adipocyte
58
20
34
4.8-16
9.13%
Biological process
Skin fibrosis
83
22
26
3.29-17
9.09%
Disease
Scavenger receptor OLR1 in inflammation-related endothelial dysfunction
73
21
28
2.8-17
9.01%
Disease
T cell differentiation block in psoriasis
52
19
36
5.87-18
8.88%
Disease
Adipokine production by adipocyte impaired in obesity
56
19
33
2.99-17
8.72%
Disease
CD40—expression targets in thymus
58
19
32
4.67-10
8.64%
Biomarkers
Lymphocyte-mediated myocardial injury in myocarditis
