MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression

Figure 2

Antagomir-21 reduces liver injury and inflammation. (a, b) Histological analysis of livers. Tissue damages were scored in a scale of 0–4, with 0, 1, 2, 3, and 4 corresponding to 0%, <25%, 26%–50%, 51%–75%, and ≥76% of liver injury, respectively. (c, d) The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. (e–g) ELISA assay was used to determine the levels of TNF-α, IL-1β, and IL-6 in livers. (h–i) ELISA assay was used to determine the levels of TNF-α, IL-1β, and IL-6 in serum. , .

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