PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB

<div>Repeated WY-14643 administration reduced inflammation in CCI rats by activating PPARα. (a) WY-14643 reduced IL-1β, IL-6, and TNF-α levels in serum of CCI rats, whereas GW6471 and si-SIRT1 reversed the anti-inflammatory effect. (b) WY-14643 reduced IL-1β, IL-6, and TNF-α levels in the spinal cord of CCI rats, whereas GW6471 and si-SIRT1 reversed the anti-inflammatory effect.</div>

PPAR Research

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Figure 3

Figure 3: PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB