Review Article
Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma
Table 2
Proinflammatory lipid mediators and their functions.
| Mediator | Function | Reference |
| LT family | LTC4 | Bronchoconstriction | [101–104] | LTD4 | Bronchoconstriction | LТЕ4 | Bronchoconstriction | LTF4 | — | LTA4 | — | LTB4 | Mediates chemotaxis, plasma exudation, reduction of lung parenchyma |
| Prostanoid family | PGI2 | Vasodilation, inhibitory effect on platelet aggregation | [43, 44, 92, 94, 105–107, 109, 110] | PGE2 | Bronchoconstriction, bronchodilation, activation of autonomic neurotransmitter pyrogenic hyperalgesia | РGF2 | Bronchoconstriction | PGD2 | Bronchoconstriction | 15d-PGJ2 | Antioxidant effect | TxA2 | Vasoconstriction | Eoxin family | A4, C4, D4, E4 | The development of allergy |
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