Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts

Figure 1

Summary of procedures. Extravillous cytotrophoblasts (EVCTs, HLAG+ cells) ^[22] and villous cytotrophoblasts (VCTs, CD49f+ cells) were isolated from human first trimester and term placental chorionic villi, respectively, treated with rosiglitazone, and analyzed using microarrays. Differentially expressed genes (DEGs) were filtered for quality control and submitted for annotation. Terms associated with DEGs and predictions of PPARγ-target genes were compared between the rosiglitazone-treated EVCTs and VCTs. PPARγ: peroxisome proliferator-activated receptor γ. The top graphic was modified from Handschuh et al. (2007).