Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet

Figure 2

MCD diet increased hepatic polyunsaturated fatty acids independently of hepatocyte PPARγ and CD36 expression. (a) Relative liver weight. (b) Hepatic triglycerides (Liv TG) levels. Hepatic levels of (c) total fatty acid levels, (d) individual subspecies of fatty acid methyl esters, (e) de novo lipogenesis (DNL: 16/18 : 2 ()) index, (f) saturated fatty acids (SFA), (g) monounsaturated fatty acids (MUFA), and (h) polyunsaturated fatty acids (PUFA). Values are represented as the . Letters represent significant differences between MSD and MCD within the group. ^A; ^B; ^C; ^D. Control mice (C); Pparg^ΔHep mice (KO); Pparg^ΔHep mice with hepatocyte Cd36 overexpression (KO+Cd36). MSD diet: open columns; MCD diet: close columns. mice/group.

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