Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy

Figure 7

Model of synergistic antitumor effects of GW6471 and hydroxychloroquine in 786-O cells. GW6471 can induce apoptosis and autophagy in 786-O cells. Hydroxychloroquine can inhibit autophagy induced by GW6471 in 786-O cells. Apoptosis can be potentiated in 786-O cells cotreated with GW6471 and hydroxychloroquine compared with being treated GW6471 only.