Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway

Figure 2

Pemafibrate can significantly alleviate the changes of liver structure and function after ischemia-reperfusion. (a) In three time points, the transaminase level of IRI mice increased significantly and improved after treatment, showing a dose-dependent. ALT and AST levels were expressed by . (b) H&E-stained hepatic sections were examined under light microscopy and imaged at a ×20 magnification. In the IRI group, there were a lot of eosinophilic and unorganized necrotic areas (circled by green lines) and increased inflammatory reactions (indicated by black arrows). However, this phenomenon was alleviated by PEM. Data was given as (, ^# for Sham versus IRI, for IRI + PEM 0.1 mg/kg versus IRI, ^! for IRI + PEM 0.1 mg/kg versus IRI + PEM 0.5 mg/kg, and ⁺ for IRI + PEM 0.5 mg/kg versus IRI + PEM 1.0 mg/kg; (a) two-way ANOVA; (b) Student’s -test).

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