Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway

Figure 6

Kupffer cells produce a number of inflammatory mediators, which can bind to cell membrane receptors, promote JAK2, and inhibit p-STAT3β and PPAR alpha. Once PPARα was inhibited, Bcl-2 decreased, and Bax increased, which could stimulate apoptosis and autophagy. Pemafibrate can inhibit the release of inflammatory factors and reduce the subsequent reactions. It could protect the liver from excessive programmed cell death by increasing the levels of p-STAT3β and PPARα in the hepatic IRI.