Research Article
miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
Figure 5
miR-22-3p suppressed the proliferation and migration of BC cells via PGC1β. (a–d) Knockdown of PGC1β partially reversed miR-22-3p inhibitor-induced promotion of proliferation in MDA-MB-231 and MCF-7 cells determined by MTT assay and colony assay. (e, f) Knockdown of PGC1β partially reversed miR-22-3p inhibitor-induced promotion of migration in MDA-MB-231 and MCF-7 cells determined by transwell assay. (g–i) Western blotting analysis for PGC1β/PPARγ protein level in MDA-MB-231 and MCF-7 cells. ; ; ; .
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |
(g) |
(h) |
(i) |