miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ

Figure 6

Inhibition of PPARγ attenuates suppression of miR-22-3p on BC cells. (a) Upregulated miR-22-3p increased the expression of PPARγ and decreased the expression of PGC1β, C-myc, NF-κB, CyclinD1, cyclin E, MMP2, and MMP9. (b) Downregulation of C-myc, NF-κB, CyclinD1, cyclin E, MMP2, and MMP9 induced by miR-22-3p was inverted by PPARγ inhibition (GW9662).

(a)

(b)