Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A

Figure 5

Fenofibrate decreased the content of DNMT1 and increased the expression of tumor suppressor genes. (a) qRT-PCR analysis of DNMT1 and PPARA mRNA expression in HCT116 and SW480 cells following fenofibrate treatment. Data was presented as (, , ). (b) The mRNA expression of p21, p27, CDKN2A, MLH1, RASSF1A, APC, GSTP1, H4F2, ACOX1, Oct4, Nanog, and Sox9 was measured. Data was presented as (, , ). (c) DMNT1 value was measured using ELISA kit. Data was presented as (, , ).

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