Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A

<div>DNMT1 repressed CDKN2A expression by promoter hypermethylation. (a) MSP results showed the methylation status of CDKN2A following fenofibrate treatment. (M: reactions using CDKN2A primers specific for methylated CpG sites; U: reactions using CDKN2A primers specific for unmethylated CpG sites). (b) The mRNA expression of DNMT1 and CDKN2A in cells was measured using qRT-PCR. 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PPAR Research

fig6

Figure 6

Figure 6: Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A 