Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A

Figure 8

Fenofibrate suppressed tumor growth and DNMT1 content in vivo. (a) Representative images of subcutaneous xenografts from the treatment and vehicle groups ( mice per group). Subcutaneous xenograft growth curves of nude mice of the two groups. Body weight of each mouse was recorded every three days. Data was presented as . (b) H&E staining of subcutaneous xenografts from the treatment group and vehicle group (magnification 200x). (c) The DNMT1 value of tissues was examined using ELISA assay. Data was presented as (, , ). (d) DNMT1, PPARA, CDK4, and CDKN2A mRNA expressions of xenografts from two groups were detected using qRT-PCR. Data was shown as (, , ). (e) DNMT1, PPARA, CDK4, and CDKN2A protein levels in different groups were measured by western blot.

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