Research Article
Fenofibrate Protects Cardiomyocytes from Hypoxia/Reperfusion- and High Glucose-Induced Detrimental Effects
Figure 6
Fenofibrate (10 μM) decreased the expression of the NADPH oxidase subunits in primary cultures of cardiomyocytes undergoing hypoxia/reperfusion (H/R), high glucose (HG), and the combination of both conditions (HG+H/R). (a) Protein expression and densitometric analysis of the p47phox subunit expression. (b) Protein expression and densitometric analysis of the NOX4 subunit expression. ND = not detectable; DMSO = dimethylsulfoxide (0.1%); Feno = fenofibrate (10 μM). # vs. control-DMSO; vs. H/R-DMSO; & vs. HG-DMSO; $ vs. HG+H/R-DMSO. Values represent the of 6 different experiments. Two-way analysis of variance (ANOVA) followed by Tukey’s post hoc test.
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