PPAR-γ Agonist Pioglitazone Restored Mouse Liver mRNA Expression of Clock Genes and Inflammation-Related Genes Disrupted by Reversed Feeding
Table 2
Effects of feeding intervention and PG intake on the level of biochemical substrates in mouse sera.
Indices
Time of feeding
Daytime
Nighttime
Untreated mice ()
PG at 7 AM ()
PG at 7 PM ()
Control mice ()
PG at 7 AM ()
PG at 7 PM (n =12)
Glucose, mmol/l
10.27 (5.70-11.34)
8.99 (6.06-9.36)
7.42 (2.27-7.73)
3.09 (2.98-8.85)
3.28 (2.96-7.46)
2.47 (2.25-6.12)
Ceruloplasmin, mg/l
243.04 (140.88-271.50)
229.51 (105.00-268.63)
148.44 (91.38-164.63)
129.25 (113.75-148.75)
134.94 (101.50-154.88)
122.50 (107.63-155.75)
Triglycerides, mmol/l
1.42 (1.03-1.48)
0.84 (0.77-1.31)
0.79 (0.77-1.05)
0.85 (0.52-1.16)
0.83 (0.66-1.06)
0.76 (0.57-0.85)
Total cholesterol, mmol/l
3.52 (2.09-3.88)
2.90 (1.68-3.51)
2.07 (1.79-2.91)
1.70 (1.61-2.96)
1.85 (1.53-3.18)
1.56 (1.46-2.87)
ALT, U/l
113.40 (99.15-121.45)
107.10 (95.65-116.35)
81.45 (74.54-91.60)
64.60 (62.67-66.85)
69.87 (64.66-73.30)
72.91 (69.85-75.54)
AST, U/l
107.51 (95.84-113.18)
98.05 (88.79-102.16)
87.00 (78.14-92.01)
79.78 (75.84-84.31)
75.91 (70.95-86.91)
89.04 (83.88-93.75)
value: : when compared with control mice (nighttime); : when compared with PG at 7 AM (nighttime); : when compared with PG at 7 PM (nighttime); : when compared with untreated mice; and : when compared with PG at 7 AM (daytime).
