Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPAR<i>α</i> Pathway

<div>Probable mechanisms of luteolin against HIRI. Hepatic IR injury will activate Kupffer cells, thus producing several inflammatory cytokines, including IL-1<i>β</i>, IL-6, and TNF-<i>α</i>. Luteolin pretreatment can inhibit this process to alleviate liver injury. Luteolin can additionally regulate autophagy and apoptosis through ERK/PPAR<i>α</i> pathway.</div>

PPAR Research

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Figure 7

Figure 7: Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPAR<i>α</i> Pathway 

Figure 7 | Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPARα Pathway 