PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression

<div>MRM chromatograms and plausible BCAA fragmentations. (a) Separation of BCAAs was achieved with UHPLC gradient to deliver distinct retention times of the product ions following optimized collision energies. (b) The chromatographically resolved isomeric analytes of Ile and Leu could be further distinguished by producing two unique fragments at m/z 69.2 and 43.2, respectively. (c) Suggested fragmentation sites for BCAAs.</div>

PPAR Research

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Figure 4

Figure 4: PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression

Figure 4 | PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression 