With the improvement of living conditions and medical care, the average human lifespan has increased remarkably. In 2020, the World Health Organization indicated that the world’s population aged 60 years and over has risen to 1 billion. Meanwhile, age-related diseases are increasingly becoming a concern for families and society. However, the molecular mechanisms of various age-related diseases such as neurodegenerative diseases, cardiovascular diseases, obesity, diabetes, and cancer are still unknown.

The peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptor proteins, which regulate gene expression by acting as transcription factors. PPARs participate in a series of age-associated pathophysiological processes. However, whether PPARs are potential targets of therapy for age related diseases is not yet clear.

The aim of this Special Issue is to illustrate the functions of PPARs in age-related diseases and target PPARs to treat such diseases. To achieve this goal, human patient tissues, animal models, organoids, and edited cell lines may be applied. We welcome original research and review articles.

Potential topics include but are not limited to the following:

• PPARs and neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease
• PPARs and diabetes
• PPARs and obesity
• PPARs and cancer
• PPARs and cardiovascular diseases
• Novel models to study PPARs related diseases
• PPARs and aging-related epigenetic codes
• Clinical trials about PPARs related drugs