PPAR Research

Biological Network Analysis of PPAR and Related Signaling Pathways


Publishing date
01 Nov 2020
Status
Closed
Submission deadline
10 Jul 2020

Lead Editor

1National Institutes of Health, Bethesda, USA

2George Mason University, Fairfax, USA

3Elsevier, Pharma, and Life Science Research and Development Solutions, Rockville MD, USA

4Wuxi Mental Health Center of Nanjing Medical University, Wuxi, China

This issue is now closed for submissions.
More articles will be published in the near future.

Biological Network Analysis of PPAR and Related Signaling Pathways

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Numerous studies have been conducted to understand peroxisome proliferator-activated receptors (PPAR)-related diseases (over 1,000), genes, and proteins involved in PPAR signaling (over 2,600), compounds targeting this pathway (over 8,000), and the cell processes affected (over 1,000). These studies have built a solid foundation and a valuable knowledge database for functional dissection of PPAR-regulated networks which may be executed either in the wet lab or in silico. Thorough modeling of PPAR signaling and related diseases represents a significant research opportunity as a key contributor towards personalized medicine, due to its potential for precise modulation.

This special issue aims to present efforts in the integration of existing databases and knowledge-based algorithms into experimental and computational studies of PPAR signaling and related disorders. Both original research and review articles are welcome, and systematic reviews and meta-analysis studies are also within the scope.

Potential topics include but are not limited to the following:

  • Reviews and research proposing novel avenues for PPAR signaling and related diseases research, with argumentation supported by in silico modeling or aided by knowledge-based algorithms
  • In silico studies of PPAR-regulating compounds, including nutraceuticals, and their effects on healthy and diseased tissues
  • Meta/mega-analysis to build/validate novel/existing biological networks and signaling pathways and reveal PPARs functionalities in diseases
  • Experimental studies in the area of PPAR research, when experimentation is aimed at testing hypotheses derived from predictions made in silico
  • PPAR-related clinical studies rationally designed as a follow-up to analysis of existing knowledge databases

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 8859017
  • - Review Article

Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction

Olga I. Rudko | Artemii V. Tretiakov | ... | Eugene A. Klimov
  • Special Issue
  • - Volume 2020
  • - Article ID 6529057
  • - Research Article

The Model of PPARγ-Downregulated Signaling in Psoriasis

Vladimir Sobolev | Anastasia Nesterova | ... | Oxana Svitich
  • Special Issue
  • - Volume 2020
  • - Article ID 6937475
  • - Research Article

A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma

Yingkun Xu | Xiunan Li | ... | Guangzhen Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 3817573
  • - Research Article

Diet Modifies Pioglitazone’s Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression

Sakil Kulkarni | Jiansheng Huang | ... | David A. Rudnick
  • Special Issue
  • - Volume 2020
  • - Article ID 3608315
  • - Review Article

The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis

Siyue Du | Nicole Wagner | Kay-Dietrich Wagner
  • Special Issue
  • - Volume 2020
  • - Article ID 3480412
  • - Research Article

PPARD May Play a Protective Role against the Development of Schizophrenia

Xinrong Li | Sha Liu | ... | Yong Xu
  • Special Issue
  • - Volume 2020
  • - Article ID 9657380
  • - Review Article

The PPAR Ω Pocket: Renewed Opportunities for Drug Development

Åsmund Kaupang | Trond Vidar Hansen
  • Special Issue
  • - Volume 2020
  • - Article ID 1892375
  • - Research Article

Integrating Literature-Based Knowledge Database and Expression Data to Explore Molecular Pathways Connecting PPARG and Myocardial Infarction

Rongyuan Cao | Yan Dong | Kamil Can Kural
  • Special Issue
  • - Volume 2020
  • - Article ID 2510951
  • - Research Article

PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma

Shunbin Shi | Guiping Yu | ... | Julia Pia Simon
  • Special Issue
  • - Volume 2020
  • - Article ID 6287468
  • - Research Article

PPARG Drives Molecular Networks as an Inhibitor for the Pathologic Development and Progression of Lung Adenocarcinoma

Min Zhao | Xiaoyang Li | ... | Yan Kang
PPAR Research
 Journal metrics
Acceptance rate44%
Submission to final decision48 days
Acceptance to publication38 days
CiteScore7.100
Impact Factor2.953
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