PPAR Research

PPAR in Cardiovascular Disorders


Status
Published

1Institute of General Pathology and Pathophysiology, Moscow, Russia

2Baker IDI Heart and Diabetes Institute, Melbourne, Australia

3Katholieke Universiteit, Leuven, Belgium

4University of Palermo, Palermo, Italy


PPAR in Cardiovascular Disorders

Description

Converging evidence highlights the important role that peroxisome proliferation-activated receptors (PPARs) play in cardiovascular disorders. Importantly, a series of recent animal studies demonstrated the potential use of PPAR gamma agonists in cardiac surgery, where they had protective functions against ischemia/reperfusion injury and reduced the risk of graft rejection. The PPARs are also important in regulating inflammation, endothelial function, angiogenesis, and hypertension. Broadening the clinical use of PPAR agonists would contribute significantly to the improvement of patient care in many cardiovascular conditions. We would like to summarize the recent progress in a special issue in this journal dedicated to the role of PPARs in cardiovascular disorders.

We invite investigators to submit original research and review articles that will contribute to the understanding of the role of PPARs in cardiovascular disorders and provide new data on the use of PPAR agonists for treatment of cardiovascular conditions.

Potential topics include, but are not limited to:

  • PPARs in pathogenesis and treatment of atherosclerosis
  • PPARs agonists: potential treatments for atherogenic dyslipidemia
  • Clinical and preclinical use of natural and synthetic PPAR agonists
  • PPARs signaling in the cardiovascular system
  • Role of PPAR during cardiovascular surgical interventions
  • Implication of PPARs in inflammatory processes
  • Improvement of allograft survival

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6293629
  • - Editorial

PPAR in Cardiovascular Disorders

Alexander N. Orekhov | Nigora Mukhamedova | ... | Manfredi Rizzo
  • Special Issue
  • - Volume 2016
  • - Article ID 4518754
  • - Research Article

Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα

Jing Yang | Fengyue Wang | ... | Lu Fu
  • Special Issue
  • - Volume 2016
  • - Article ID 7407153
  • - Clinical Study

Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR

Zhongxia Wang | Tao Zhang | ... | Tao Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 2198645
  • - Review Article

Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis

Huang-Jun Liu | Hai-Han Liao | ... | Qi-Zhu Tang
  • Special Issue
  • - Volume 2016
  • - Article ID 9174190
  • - Research Article

Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKT/GSK3β and MAPK Signaling Pathways

Wen-Ying Wei | Zhen-Guo Ma | ... | Qi-Zhu Tang
  • Special Issue
  • - Volume 2016
  • - Article ID 9282087
  • - Research Article

Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats

Giselle Barreto-Torres | Sabzali Javadov
  • Special Issue
  • - Volume 2016
  • - Article ID 7631085
  • - Research Article

Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor Beta/Delta Leads to Rapid Cardiac Hypertrophy

Kay-Dietrich Wagner | Ana Vukolic | ... | Nicole Wagner
  • Special Issue
  • - Volume 2016
  • - Article ID 7508026
  • - Research Article

The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression

E. Czarnowska | D. Domal-Kwiatkowska | ... | R. Wojnicz
  • Special Issue
  • - Volume 2016
  • - Article ID 4934251
  • - Research Article

Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

Aleš Pleskovič | Marija Šantl Letonja | ... | Danijel Petrovič
  • Special Issue
  • - Volume 2015
  • - Article ID 271983
  • - Review Article

Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions

Wang-Soo Lee | Jaetaek Kim
PPAR Research
 Journal metrics
Acceptance rate44%
Submission to final decision48 days
Acceptance to publication38 days
CiteScore7.100
Impact Factor2.953
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