PPAR Research

PPARs: Regulators and Translational Targets in the Lung


Publishing date
15 Jun 2012
Status
Published
Submission deadline
15 Jan 2012

Lead Editor

1Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta VAMC, 1670 Clairmont Road, Atlanta, GA 30033, USA

2Division of Pulmonary, Critical Care and Sleep Disorders Medicine, Department of Medicine, University of Louisville School of Medicine, 505 Hancock Street, Louisville, KY 40202, USA

3Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA

4Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA 90502, USA


PPARs: Regulators and Translational Targets in the Lung

Description

Peroxisome proliferator-activated receptors (PPARs) were originally identified primarily as regulators of glucose and lipid metabolism. Both PPAR-γ and PPAR-α agonists are widely used clinically for treatment of diabetes and dyslipidemia. More recently, the pivotal role of PPARs in modulating a variety of physiological activities in cell types throughout the body has been recognized. In the lung, they regulate the immune response, inflammation, surfactant production, differentiation, proliferation, and apoptosis of a variety of cells. Even as investigation continues into the fundamental biology of PPARs and the mechanisms through which they act, other studies examine their potential as therapeutic targets. Current progress on both fronts has been and continues to be rapid. We invite authors to contribute review articles describing recent advances in the field as well as original research articles reporting significant new findings. We are interested in articles describing either basic or translational research as well as those illustrating the relationship between the two. Reports of clinical studies are also welcome. Potential topics include, but are not limited to:

  • Molecular biology of PPARs
  • Signaling pathways controlling PPAR expression or through which PPARs act
  • Role of PPARs in specific lung cells (e.g., alveolar macrophages and airway epithelial cells)
  • Role of PPARs in physiological processes related to the lung
  • Role of PPARs in specific lung diseases (e.g., asthma, fibrosis, and cancer)

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ppar/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 342924
  • - Editorial

PPARs: Regulators and Translational Targets in the Lung

Raju C. Reddy | Virender K. Rehan | ... | Patricia J. Sime
  • Special Issue
  • - Volume 2012
  • - Article ID 375876
  • - Research Article

TGF 𝜷 1 Controls PPAR 𝜸 Expression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts

Allan Ramirez | Erin N. Ballard | Jesse Roman
  • Special Issue
  • - Volume 2012
  • - Article ID 809164
  • - Review Article

PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy

Chantal Donovan | Xiahui Tan | Jane Elizabeth Bourke
  • Special Issue
  • - Volume 2012
  • - Article ID 617063
  • - Research Article

The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice

Aravind T. Reddy | Sowmya P. Lakshmi | Raju C. Reddy
  • Special Issue
  • - Volume 2012
  • - Article ID 383829
  • - Review Article

PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing

Patricia E. Almeida | Alan Brito Carneiro | ... | Patricia T. Bozza
  • Special Issue
  • - Volume 2012
  • - Article ID 604216
  • - Research Article

Prenatal Rosiglitazone Administration to Neonatal Rat Pups Does Not Alter the Adult Metabolic Phenotype

Hernan Sierra | Reiko Sakurai | ... | Virender K. Rehan
  • Special Issue
  • - Volume 2012
  • - Article ID 235231
  • - Research Article

The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils

Steven G. Smith | Haruki Imaoka | ... | Gail M. Gauvreau
  • Special Issue
  • - Volume 2012
  • - Article ID 289867
  • - Review Article

PPARγ Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the Lung

Virender K. Rehan | John S. Torday
  • Special Issue
  • - Volume 2012
  • - Article ID 705352
  • - Review Article

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases

Ajit A. Kulkarni | Collynn F. Woeller | ... | Patricia J. Sime
  • Special Issue
  • - Volume 2012
  • - Article ID 256874
  • - Review Article

PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases

Yongchun Shen | Lei Chen | ... | Fuqiang Wen
PPAR Research
 Journal metrics
Acceptance rate44%
Submission to final decision48 days
Acceptance to publication38 days
CiteScore7.100
Impact Factor2.953
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