PPAR Research

PPARs and Liver Disease

Publishing date
14 Dec 2012
Submission deadline
27 Jul 2012

Lead Editor

1Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai City, Miyagi 980-8574, Japan

2Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai City, Miyagi 980-8574, Japan

3Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA

4Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 0165, USA

PPARs and Liver Disease


Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and have been implicated in a variety of pathologic process. PPARs require heterodimerization with receptor X for retinoids (RXR) to have function. PPARα/β/δ/γ, with RXR, are important nuclear receptors expressed in the liver and contribute to the control of glucose and lipid metabolism, cell proliferation and inflammation, and so forth. PPARs became considered as the target molecules of human metabolic disease such as nonalcoholic fatty liver disease (NAFLD) including NASH, since PPAR activation has been associated with anti-inflammatory and antifibrotic functions in the liver. Among the liver disease, PPARs could contribute to the pathogenesis of chronic hepatitis C (CHC), chronic hepatitis B (CHB), and hepatocellular carcinoma (HCC) in addition to NAFLD. For example, HCV infection is characterized by disturbance of glucose and lipid metabolism leading to fat accumulation in hepatocytes. Therefore, the varieties of liver disease are also related to the PPARs. In this special issue, we should collect various kinds of research and review articles regarding PPARs and liver diseases to understand the detailed contribution of PPARs in liver diseases. Potential topics include, but are not limited to:

  • PPARs and NAFLD (control of lipid and lipoprotein metabolism)
  • PPARs and alcohol-induced liver diseases (Anti-inflammatory immunomodulatory properties)
  • PPARs and hepatitis C virus persistent infection
  • PPARs on viral transcription and replication during hepatitis B virus persistent infection
  • Modulation of PPARs expression during chronic hepatitis virus infection
  • PPARs and Hepatocellular carcinoma
  • PPARs and liver immunology
  • PPARs and hepatic glucose metabolism
  • PPARs and recent topic of liver diseases
  • Treatment of liver diseases using PPAR ligands

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ppar/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


  • Special Issue
  • - Volume 2013
  • - Article ID 896412
  • - Editorial

PPARs and Liver Disease

Yasuteru Kondo | Kenji Uno | ... | Masanori Terajima
  • Special Issue
  • - Volume 2013
  • - Article ID 452061
  • - Review Article

Peroxisome Proliferator-Activated Receptor Genetic Polymorphisms and Nonalcoholic Fatty Liver Disease: Any Role in Disease Susceptibility?

Paola Dongiovanni | Luca Valenti
  • Special Issue
  • - Volume 2012
  • - Article ID 574180
  • - Review Article

PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma

Osamu Kimura | Yasuteru Kondo | Tooru Shimosegawa
  • Special Issue
  • - Volume 2012
  • - Article ID 107434
  • - Review Article

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

Luis A. Videla | Paulina Pettinelli
  • Special Issue
  • - Volume 2012
  • - Article ID 940384
  • - Research Article

Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus

Yuji Ogawa | Masato Yoneda | ... | Atsushi Nakajima
  • Special Issue
  • - Volume 2012
  • - Article ID 738785
  • - Review Article

Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury

Zhixin Gao | Yuan-Hai Li
PPAR Research
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Acceptance rate45%
Submission to final decision71 days
Acceptance to publication43 days
Impact Factor4.186