Table of Contents
Pathology Research International
Volume 2011, Article ID 934350, 5 pages
Clinical Study

Salivary Gland Tumors in Maxillofacial Region: A Retrospective Study of 130 Cases in a Southern Iranian Population

1Departments of Otolaryngology and Maxillofacial Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
3Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, P.O. Box 71935-1119, Shiraz, Iran

Received 11 October 2010; Accepted 10 May 2011

Academic Editor: Edward B. Stelow

Copyright © 2011 Mahmoud Shishegar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumors of the salivary glands are uncommon head and neck neoplasia. We conducted a retrospective study of 392 cases over the last 6 years in Shiraz, south of Iran, to investigate the clinicopathological features of these tumors in Iranian population. The age of the patients ranged from 8 to 85 years, with the mean age 4 4 . 5 7 ± 1 4 . 6 5 years and male-to-female (M : F) ratio was 1.02 : 1. For benign tumors, there was a propensity towards females, whereas the malignant tumor was more common in males. The ratio of benign tumors to malignancies was 2.19 : 1. Pleomorphic adenoma (PA) was the most common tumor and accounted for 85% of all benign tumors, followed by Warthin's tumor (8.6%). Of the 125 malignancies, adenoid cystic carcinoma (40%), mucoepidermoid carcinoma (24%) and invasive squamous cell carcinoma (16%) were the most common histological types. Most of the salivary gland tumors (75%) originated from major salivary glands and the remained (25%) originated from minor glands. The parotid gland was the most common site both in benign and malignant tumors. Most of our findings were similar to those in the literature, with some variations. The salivary tumors slightly predominated in males. Adenoid cystic carcinoma and mucoepidermoid carcinoma constituted the most common malignancies.