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Pathology Research International
Volume 2012 (2012), Article ID 273701, 8 pages
Review Article

Animal Models in Behçet's Disease

Department of Ophthalmology, Faculty of Medicine, Mersin University, 33070 Mersin, Turkey

Received 26 August 2011; Revised 3 November 2011; Accepted 4 November 2011

Academic Editor: Ümit Tursen

Copyright © 2012 Ozlem Yildirim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been proposed, including environmental, infectious, and immunological factors; an autoimmune basis, characterized by circulating immune complexes and complement activation, has gained increasing acceptance. To test and understand immunopathogenesis of Behçet's disease, animal models were developed based on enviromental pollutants, bacterial and human heat shock protein derived peptides, and virus injections. Using these animal models separately and/or concurrently allows for a more effective investigation into Behçet's disease. Animal models developed in the last 10 years aim at the development of efficient and safe treatment options.