Clinical Study

Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients

Table 1

Clinical characteristics, treatment, and outcome of the patients.

PAge/sexUnderlying conditionsSigns and symptomsRadiologic findingsTreatmentOutcome

138/MTerminal HIV; CD4: 7/ LFever, abdominal pain, diarrhea CT: retroperitoneal adenopathiesCL + RIF + ETMDeath (1 month)

238/FHIV (2 months); CD4: 9/ L; Wilson’s diseaseFever, productive cough; abdominal pain, lower limb xerosisCXR: bilateral interstitial pattern, LUL condensation; AXR: right echogenic imageINH + RIF + PRZRecovery

335/MHIV ( 1 m); CD4: 9/ LFever, cough, abdominal pain, enlarged cervical lymph nodesCT: retroperitoneal and mesenteric adenopathies; mesenteric edemaAZ + ETM + AKRecovery

466/MKidney Tx (2004); CD4: 85/ LFever, productive cough; abdominal pain, anemia, bilateral tibiomaleolar oedemaCXR: blunting of right costophrenic angle; ARX: left echogenic image; colonoscopy: multiple adenomatous polypsCL + ETM + LEVRecovery

528/FAML (UCBT, 2009)Fever, anemia, abdominal pain, diarrhea, ankle and leg oedema CXR: RUL micronodule; CT: pericardial effusion, pleural thickening; endoscopy: duodenal villous hypertrophyFirst ETM + AK + LIN;
then CL + RIB + ETM
Death (6 months)

652/FHeart Tx (2004)Fever, diarrhea, abdominal pain, ankle and leg oedema; lower limb petechiaeAbdominal Echo: hepatosplenomegaly, intra- and retroperitoneal lymphadenopathy; CXR: multiple bilateral infiltratesRIF + ETM + PRZ + LEV Death (5 months)

77/FHiper-IgE SyndromeFever, diarrhea, abdominal painCT: RLL bronchiectasiesCL + RIF + ETM + LEVRecovery

P: patient; M: male; F: female; Tx: transplantation; AML: acute myeloid leukaemia; CT: computed tomography scan; UCBT: umbilical cord blood transplantation; CXR: chest X-ray; AXR: abdominal X-ray; LUL: left upper lobe; RLL: right lower lobe; CL: clarithromycin; INH: isoniazid; RIF: rifampicin; RIB: rifabutin; ETM: ethambutol; PRZ: pyrazinamide; AZ: azithromycin; AK: amikacin; LEV: levofloxacin; LIN: linezolid.