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Pain Research and Management
Volume 18, Issue 5, Pages e63-e67
Original Article

The Analgesic Efficacy of Intra-Articular Acetaminophen in an Experimental Model of Carrageenan-Induced Arthritis

Oguzhan Arun,1,4 Ozgur Canbay,1 Nalan Celebi,1 Altan Sahin,1 Ali Konan,2 Pergin Atilla,3 and Ulku Aypar1

1Department of Anesthesiology and Reanimation, Hacettepe University, Ankara, Turkey
2Department of General Surgery, Hacettepe University, Ankara, Turkey
3Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
4Faculty of Medicine, Selcuk University, Konya, Turkey

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: Acetaminophen is one of the most common drugs used for the treatment of pain and fever.

OBJECTIVES: To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats.

METHODS: The present study was performed using 20 Sprague Dawley rats. Forty microlitres of IA 0.9% NaCl was injected in the control group, and 40 μL of IA carrageenan was injected in the carrageenan group. One hour after carrageenan injection, 400 μg of IA acetaminophen was injected in the IA acetaminophen group, and 400 μg of intraperitoneal (IP) acet-aminophen was injected in the IP acetaminophen group. One day before injection, and 4 h and 8 h after injection, diameters of both knee joints, motility of the rat, paw loading and joint mobility were assessed. After the rats were euthanized, L3 and L4 spinal segments were excised for c-Fos assessment.

RESULTS: IA acetaminophen decreased both the severity and distribution of c-Fos expression. IP acetaminophen decreased only the distribution of c-Fos expression. IA acetaminophen decreased knee diameter at 8 h. IA and IP acetaminophen increased rat motility and paw loading scores. Joint mobility scores of IP acetaminophen were similar to saline at 8 h.

CONCLUSIONS: Results of the present study indicate an analgesic and/or possible anti-inflammatory effect of IA acetaminophen and provide further evidence on the efficacy of systemic acetaminophen injection in reducing arthritic pain.