Pain Research and Management

Pain Research and Management / 2013 / Article

Original Article | Open Access

Volume 18 |Article ID 270183 |

Ceferino Maestú, Manuel Blanco, Angel Nevado, Julia Romero, Patricia Rodríguez-Rubio, Javier Galindo, Juan Bautista Lorite, Francisco de las Morenas, Pedro Fernández-Argüelles, "Reduction of Pain Thresholds in Fibromyalgia after Very Low-Intensity Magnetic Stimulation: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial", Pain Research and Management, vol. 18, Article ID 270183, 6 pages, 2013.

Reduction of Pain Thresholds in Fibromyalgia after Very Low-Intensity Magnetic Stimulation: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial


BACKGROUND: Exposure to electromagnetic fields has been reported to have analgesic and antinociceptive effects in several organisms.OBJECTIVE: To test the effect of very low-intensity transcranial magnetic stimulation on symptoms associated with fibromyalgia syndrome.METHODS: A double-blinded, placebo-controlled clinical trial was performed in the Sagrado Corazón Hospital, Seville, Spain. Female fibromyalgia patients (22 to 50 years of age) were randomly assigned to either a stimulation group or a sham group. The stimulation group (n=28) was stimulated using 8 Hz pulsed magnetic fields of very low intensity, while the sham group (n=26) underwent the same protocol without stimulation. Pressure pain thresholds before and after stimulation were determined using an algometer during the eight consecutive weekly sessions of the trial. In addition, blood serotonin levels were measured and patients completed questionnaires to monitor symptom evolution.RESULTS: A repeated-measures ANOVA indicated statistically significant improvement in the stimulation group compared with the control group with respect to somatosensory pain thresholds, ability to perform daily activities, perceived chronic pain and sleep quality. While improvement in pain thresholds was apparent after the first stimulation session, improvement in the other three measures occurred after the sixth week. No significant between-group differences were observed in scores of depression, fatigue, severity of headaches or serotonin levels. No adverse side effects were reported in any of the patients.CONCLUSIONS: Very low-intensity magnetic stimulation may represent a safe and effective treatment for chronic pain and other symptoms associated with fibromyalgia.

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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