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Pain Research and Management
Volume 18 (2013), Issue 2, Pages 94-96
Original Article

Effects of Gabapentin on Pain and Opioid Consumption after Abdominal Hysterectomy

Fatemeh Frouzanfard,1 Mohammed Reza Fazel,2 Azadeh Abolhasani,1 Esmaeil Fakharian,2 Golmabas Mousavi,3 and Alireza Moravveji4

1Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran
2Trauma Research Centre, Kashan University of Medical Sciences, Kashan, Iran
3Department of Biostatistics and Public Health, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran
4Department of Community Medicine, Kashan University of Medical Sciences, Kashan, Iran

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: Postoperative pain is an important factor affecting anesthesia and surgery.

OBBJECTIVES: The present study assessed the effects of 1200 mg gabapentin, an anticonvulsant drug that acts through voltage-dependent calcium channels, for the control of postoperative pain in patients undergoing abdominal hysterectomy.

METHODS: Fifty patients undergoing hysterectomy were enrolled in the present study. Subjects received either 1200 mg gabapentin or placebo 2 h before surgery. The amount of morphine consumption and level of postoperative pain at 2 h, 6 h, 12 h and 24 h after surgery were measured.

RESULTS: There were no significant differences in age, duration of surgery and anesthesia, or body mass index between the two groups. The mean intensity of pain in the gabapentin group was significantly lower than in the placebo group. The mean amount of morphine used in the placebo group (5.2±2.8 mg) was significantly higher than in gabapentin group (1.2±0.29 mg; P=0.001). Nausea and vomiting in the placebo group was more common than in the gabapentin group (P=0.001). The time interval for initial ambulation after surgery was significantly shorter in the gabapentin group (12.24±2.18 h) compared with the placebo group (15±3.61 h; P=0.002).

CONCLUSION: 1200 mg gabapentin reduced postoperative pain and the need for opioids, and enabled earlier ambulation of the patient. Significant side effects were not observed.