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Pain Research and Management
Volume 2016, Article ID 2487924, 6 pages
Research Article

Relationship between Neuropathic Pain and Obesity

1Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan
2Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo 113-8655, Japan
3Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan
4Department of Orthopaedic Surgery, Jichi University, Graduate School of Medicine, Tochigi, Japan

Received 9 July 2015; Accepted 23 December 2015

Copyright © 2016 Jun Hozumi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain. This was conducted to determine if obesity affects neuropathic pain, usually considered unrelated to the weight-load on the musculoskeletal system. Methods. Using a cut-off body mass index value of 25, 44 patients with neuropathic pain were grouped into a “high-BMI” group and a “normal-BMI” group. Results. The numeric rating scale of the high-BMI group was significantly higher than that of the normal-weight group (). The total NPSI scores were significantly higher (), and the paroxysmal pain and the negative symptoms were more serious in the high-BMI group than in the normal-BMI group. The high-BMI subjects also had significantly higher SF-MPQ scores (). However, both physical and mental health status on the SF-36 were comparable between the groups. Discussion. Neuropathic pain that did not arise from musculoskeletal damage was higher in the high-BMI patients. Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation. These findings should have needed to be confirmed in future studies.