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Pain Research and Management
Volume 2016, Article ID 3256583, 5 pages
Clinical Study

Comparison of the Effects of Intrathecal Fentanyl and Intrathecal Morphine on Pain in Elective Total Knee Replacement Surgery

1Anesthesiology and Reanimation Clinic, Bor State Hospital, Niğde, Turkey
2Anesthesiology and Reanimation Clinic, Mardin State Hospital, Mardin, Turkey
3Anesthesiology and Reanimation Clinic, Niğde State Hospital, Niğde, Turkey
4Medical Biostatistics Department, Çukurova University, Adana, Turkey

Received 16 October 2016; Accepted 28 November 2016

Academic Editor: Rudin Domi

Copyright © 2016 Refika Kılıçkaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Total knee replacement is one of the most painful orthopedic surgical procedures. In this study, our goal was to compare the intraoperative and postoperative hemodynamic effects, the side effects, the effect on the duration of pain start, the 24-hour VAS, and the amount of additional analgesia used, of the fentanyl and morphine we added to the local anesthetic in the spinal anesthesia we administered in cases of elective knee replacement. Materials and Methods. After obtaining the approval of the Erciyes University Medical Faculty Clinical Drug Trials Ethics Committee, as well as the verbal and written consent of the patients, we included 50 patients in our prospective, randomized study. Results. In our study, the morphine group (Group M) had lower pain scores in the 2nd, 6th, 12th, and 24th hours compared to the fentanyl group (Group F). When additional analgesic requirements were compared, it was found that in the 2nd, 6th, and 24th hours fewer Group M patients needed more analgesics than did Group F patients. Conclusion. The fentanyl group also had lower first analgesic requirement times than did the morphine group. In terms of nausea and vomiting, there was no statistically significant difference between the two groups.