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Pain Research and Management
Volume 2016, Article ID 5079675, 10 pages
Clinical Study

Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study

1Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
2Department of Orthopaedic Surgery, Japan Community Health Care Organization Funabashi Central Hospital, Funabashi 273-0021, Japan
3Department of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido 284-0003, Japan
4Department of Orthopaedic Surgery, Kitasato University, Sagamihara 252-0375, Japan
5Department of Orthopaedic Surgery, Tsuga Saito Orthopaedic Clinic, Chiba 264-0025, Japan
6Department of Orthopaedic Surgery, Showa University, Tokyo 142-8666, Japan
7Department of Orthopaedic Surgery, Chiba Cancer Center, Chiba 260-0801, Japan
8Department of Orthopaedic Surgery, Sanmu Medical Center, Sanmu 289-1326, Japan
9Department of Orthopaedic Surgery, Eastern Chiba Medical Center, Togane 283-8686, Japan
10Department of Orthopaedic Surgery, Kumagaya General Hospital, Kumagaya 360-0013, Japan
11Department of Orthopaedic Surgery, Japan Community Health Care Organization Chiba Hospital, Chiba 260-8710, Japan
12Department of Orthopaedic Surgery, Chiba National Medical Center, Chiba 260-0042, Japan
13Department of Orthopaedic Surgery, Funabashi Municipal Medical Center, Funabashi 273-8588, Japan

Received 17 October 2015; Accepted 27 November 2015

Copyright © 2016 Sumihisa Orita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. Subjects were a total of 104 LSS patients with neuropathic pain (NeP) in leg and neurological intermittent claudication (IMC) refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) for at least a month. NeP was identified using screening tool, Pain DETECT questionnaire. Visual analog scale (VAS) scores and responses to the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were assessed before and 6 weeks after PGB treatment initiation. Changes in IMC distance and adverse events were also recorded. PGB significantly improved their VAS scores for pain and sleep quality (). With respect to JOABPEQ, significant improvements were observed with regard to the following dimensions: pain-related disorders (), lumbar spine dysfunction (), gait disturbance (), and psychological disorders (). The IMC distance showed an improvement tendency after PGB treatment, albeit with no significance (). Minor adverse events such as dizziness were observed. PGB can be effective for neuropathic leg pain refractory to NSAIDs in LSS patients, resulting in not only pain control but also improving lower back pain-related ADL/QOL scores.