How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review

Table 2

Description of deaths reported in Health Canada’s Vigilance Adverse Reaction Online Database.

Age	Source of report	Medication	Other relevant information
2 years	Nonhealth professional	Morphine (no route or dosing information)	Respiratory failure was reported
18 years	Physician	Tylenol and acetaminophen plus codeine (both oral; no dosing information)	None reported
4 years	Nonphysician health professional	Acetaminophen plus codeine (oral; no dosing information)	Patient described as having a medically important condition. Respiratory distress was reported
3 months (4 kg)	Nonphysician health professional	Acetaminophen	Apnea, cyanosis, respiratory depression, and supratherapeutic drug levels were reported