Pain Research and Management / 2017 / Article / Tab 2

Clinical Study

Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery

Table 2

Patient characteristics and medical conditions.

Safety setBuprenorphine transdermal system ()Oral tramadol/acetaminophen () value

Sex, male, (%)25 (36.2)29 (44.6)0.3228
Age, mean ± SD, years64.4 ± 10.861.5 ± 9.00.0969
Age distribution, (%)
 ≥70 years, (%)24 (34.8)11 (16.9)0.0637
 60–69 years, (%)27 (39.1)30 (46.1)
 50–59 years, (%)12 (17.4)20 (30.8)
 <50 years, (%)6 (8.7)4 (6.1)
Weight (baseline), mean ± SD, kg62.2 ± 9.462.0 ± 10.20.9176
Period after lumbar fusion surgery, mean ± SD, days20.9 ± 11.819.2 ± 9.50.3532
 10 days to <1 month, (%)61 (88.4)57 (87.7)0.8987
 ≥1 month, (%)8 (11.6)8 (12.3)
History of medical or allergy condition over past 2 years, (%)55 (79.7)57 (87.7)0.2125
Used prior medication within 4 weeks of baseline visit, (%)68 (98.6)64 (98.5)1.0000
Had ≥1 dose of analgesics or drugs with analgesic effect during the study, other than study or rescue medication7 (10.1)7 (10.8)0.9060

-square or Fisher’s exact test.

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