Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery
Table 2
Patient characteristics and medical conditions.
Safety set
Buprenorphine transdermal system ()
Oral tramadol/acetaminophen ()
value
Sex, male, (%)
25 (36.2)
29 (44.6)
0.3228
Age, mean ± SD, years
64.4 ± 10.8
61.5 ± 9.0
0.0969
Age distribution, (%)
≥70 years, (%)
24 (34.8)
11 (16.9)
0.0637
60–69 years, (%)
27 (39.1)
30 (46.1)
50–59 years, (%)
12 (17.4)
20 (30.8)
<50 years, (%)
6 (8.7)
4 (6.1)
Weight (baseline), mean ± SD, kg
62.2 ± 9.4
62.0 ± 10.2
0.9176
Period after lumbar fusion surgery, mean ± SD, days
20.9 ± 11.8
19.2 ± 9.5
0.3532
10 days to <1 month, (%)
61 (88.4)
57 (87.7)
0.8987
≥1 month, (%)
8 (11.6)
8 (12.3)
History of medical or allergy condition over past 2 years, (%)
55 (79.7)
57 (87.7)
0.2125
Used prior medication within 4 weeks of baseline visit, (%)
68 (98.6)
64 (98.5)
1.0000
Had ≥1 dose of analgesics or drugs with analgesic effect during the study, other than study or rescue medication
