Pain Research and Management / 2017 / Article / Tab 5

Clinical Study

Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery

Table 5

Adverse events.

Safety setGroupSubjects, Number of events, Incidence, (%)95% CI (lower, upper) value

Adverse events (AE)BTDS693118 (26.1)(15.7, 36.5)0.4037
TA652213 (20.0)(10.3, 29.7)
Total1345331 (23.1)(16.0, 30.3)

Serious adverse event (SAE)BTDS6933 (4.4)(0.0, 9.2)0.2450
TA6500 (0)
Total13433 (2.2)(0.0, 4,7)

Adverse drug reaction (ADR)BTDS691914 (20.3)(10.8, 29.8)0.6171
TA651311 (16.9)(7.8, 26.0)
Total1343225 (18.7)(12.1, 25.3)

Withdrawals due to AEBTDS6954 (5.8)(0.3, 11.3)0.1201
TA6500 (0)
Total13454 (3.0)(0.1, 5.9)

-square test; test; BTDS: buprenorphine transdermal system; TA: tramadol/acetaminophen.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.