A Novel Model of Cancer-Induced Peripheral Neuropathy and the Role of TRPA1 in Pain Transduction

Figure 1

Morphological changes after AT-1 cell injection. (a) Sciatic nerves (SNs) are exposed in cancer (upper) and sham (lower) animals where the nerve thickness and the solid lump distinguish the cancerous one. (b) Signs of pain appear in the ipsilateral (right) and not in the contralateral (left) paw of the Copenhagen rat. Figures (c–e) show the gradual growth of the tumorous (upper) nerves in the cancer-injected animals at days 7 (c), 14 (d), and 21 (e). The nontumorous (lower) nerves are placed below for comparison.

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